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It was recently discoveredthat many of these patients have a single nucleotide polymorphism (SNP) in a gene thatencodes PTPN2 and is called PTPN2rs1893217. One probable vCJDsubject who died in 2009 (lighter bar) was codon 129MV andhad primary infection. The caption should act as aclear road map to direct the reader through the illustration in the most efficient manner possi-ble.

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Barbieri CE, Tang LJ, Brown KA, Pietenpol JA (2006) Loss of p63 leads to increased cellmigration and up-regulation of genes involved in invasion and metastasis.

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In this same region, one ofthe cells (upper rightcorner) embeddedwithin the osteoid exhibits a small process (arrow). About 24 different members ofthe clau-din family have been characterized to date. A lobule is best identified when itis cut in cross-section. Transcendental med-itation (TM), the relaxation response, mindfulness-based-stress-reduction, and Freeze Frame® are just afew.

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