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BL, basal (external) lamina; PV, pinocytotic vesicles. This is the primary contact involving the TCRand peptide/MHC complex that forms a central ring, which is the result of the clustering ofTCR molecules on the APC (target cell) membrane and called the central SMAC or cSMAC.A secondary ring forms composed of the interactions with the T cell‘s LFA-1 and the APC‘sICAM-1 molecules and is called the peripheral SMAC or pSMAC

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