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Despite the fact that Treg proliferation was demonstrated inthis system and allogeneic transplant systems described above; these systems are stillsomewhat artificial because specific inhibitors were used. Thesecells mentioned above arrive at an inflammatory site and secrete a number of cytotoxicproinflammatory mediators such as reactive oxygen (ROS) and nitrogen species (RNS),which are involved in oxidative DNA damage mentioned in the environmental carcinogenesissection Thesecells mentioned above arrive at an inflammatory site and secrete a number of cytotoxicproinflammatory mediators such as reactive oxygen (ROS) and nitrogen species (RNS),which are involved in oxidative DNA damage mentioned in the environmental carcinogenesissection. Aristotelian definitions were employedbecause this is a literate style that is concise andinformative (Watson, 1995).