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Roybal JL, Endo M, Radu A, Gray L, Todorow CA, Zoltick PW, Lutsenko S, Flake AW(2012) Early gestational gene transfer with targeted ATP7B expression in the liver improvesphenotype in a murine model of Wilson’s disease.

Each of these undergoes alternative splic-ing at the 3? end to generate ?, ? and ? forms and, potentially, ? and ?. If the gait instability is accompanied by ahistory of urinary incontinence, normal pressure hydro-cephalus needs to be excluded as a cause. ADhas been reported much less frequently (Kertesz et al.,2005; Knibb et al., 2006; Alladi et al., 2007) and may some-times reflect the inclusion of patients who might havebeen diagnosed by other groups as logopenic PPA usingcurrent consensus criteria. A com-plementary theoretical position to that provided by Francis has been suggested by Smaje (1996)and Nazroo (1998), when explaining ethnic inequalities in mental and physical health.

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Among patients with stable CAD,exercise has also been shown to have substantial ben-efits. In the case of oropharyngeal cancers, on the other hand, p53 muta-tion was associated with radiation resistance [78]

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